Genes found to influence tooth growth

New research suggests that the teeth of babies with certain genetic variants tend to appear later and that these children have a lower number of teeth by age one. Additionally, those children whose teeth develop later are more likely to need orthodontic treatment.

The research, led by Professor Marjo-Riitta Jarvelin of the School of Public Health at Imperial College London, scanned the entire genetic code of 6,000 individuals from the Northern Finland Birth Cohort (NFBC1966) and the Avon Longitudinal Study on Parents and Children (ALSPAC), UK, both of which track participants from early on in the mother’s pregnancy until adulthood.

The researchers identified five genes associated with both the first tooth eruption and the number of teeth at age one. They also found that one of the identified genes was associated with a 35% increased risk of requiring orthodontic treatment by the age of 30 years.

The authors emphasise that tooth development is not an isolated event. Teeth and several other organs have common growth and developmental pathways in early life. Some of the genes identified have been linked in previous studies with the development of the skull, jaws, ears, fingers, toes and heart.

Abnormal tooth development may lead to dental problems that demand challenging and costly orthodontic treatment. The discovery of genes influencing tooth growth may lead to innovations in the early treatment and prevention of congenital dental and occlusion problems.

Professor Marjo-Riitta Jarvelin said: ‘The discoveries of genetic and environmental determinants of human development will help us to understand the development of many disorders which appear later in life. We hope also that these discoveries will increase knowledge about why foetal growth seems to be such an important factor in the development of many chronic diseases.’

To access the article in full, visit www.plosgenetics.org.